About

Cordillera Labs is Alex Fraser, a bioinformatics software developer and consultant based in British Columbia, Canada.

Have a project in mind? Reach out to talk through it.

Alex holds a BSc in Computer Science and Biology from the University of British Columbia. At UBC's Michael Smith Laboratories, he was an embedded collaborator in the Brumer Lab — working directly with wet-lab researchers from experimental design through published figures, on metagenomics, RNA-seq, and CAZyme analysis. That work contributed to publications in Science, Applied and Environmental Microbiology, and the Journal of Biological Chemistry.

Alex is the lead developer of SACCHARIS 2, a bioinformatics pipeline for phylogenetic prediction of CAZyme substrate specificity. It is a full rewrite of the original Perl pipeline in Python, with Bioconda distribution and a GUI designed and built from scratch. SACCHARIS 2 is published in Methods in Molecular Biology (Springer Nature, 2024).

Earlier work included analytical chemistry research at Langara College (operating HPLC and GC/MS instrumentation, designing acquisition methods, and analysing plant compound extractions), which grounded a bench-level understanding of where experimental data comes from.

Later work at UBC involved building image analysis automation for a developmental biology lab: implementing a convolutional neural network for tooth detection and, because no existing tool handled the geometric alignment correctly, a custom algorithm using a matrix representation of conic sections to register microscopy image time series. The same instinct — formalise the problem properly rather than approximate it — is what he brings to analysis work that has no clean off-the-shelf answer.

Cordillera Labs exists because every research lab is constantly reinventing the same wheels, often under time pressure and without software engineering training. Alex's long-term goal is a world where biologists can do their work quickly, accurately, and reproducibly, sharing and building on each other's tools, without having to become programmers to get there.

What Alex works on

Core expertise

Metagenomics, RNA-seq, phylogenetic analysis, CAZyme annotation, HPC pipeline development, data analysis and visualisation in Python and R.

How Alex works best

Close to the science, where the software is in service of a real research question rather than bolted on afterward.

Engagement

Available for contract and consulting work, from a focused code review or analysis to a multi-month pipeline build or ongoing retainer.

Background breadth

Because Alex reads a chromatogram and a stack trace with equal comfort, conversations skip the long ramp-up where a developer learns the domain or a scientist learns to scope software. Work starts at the real problem.

Have a project in mind?

Tell Alex what's slowing your lab down. A 30-minute scoping call, no charge, is enough to find out where the time is going and what it would take to get it back.